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Contraindications and precautions Contraindicated in patients hypersensitive to drug and patients with anuriahepatic comaor severe electrolyte depletionContraindicated if increased azotemiaoliguriaor progressive renal disease occur during therapyUse cautiously in pregnant womenpatients with sulfa allergyand in those with hepatic cirrhosis.
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Pharmacodynamics Diuretic actionLoop diuretics inhibit sodium and chloride reabsorption in the proximal part of the ascending loop of Henlepromoting the excretion of sodiumwaterchlorideand potassiumAntihypertensive actionThis drug effect may be the result of renal and peripheral vasodilatation and a temporary increase in glomerular filtration rate and a decrease in peripheral vascular resistance.
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urine and blood glucose should be checked periodically in diabetics receiving furosemide, even in those suspected of latent diabetes.